Robustness and lethality
WebOct 29, 2010 · Mild heat stress pretreatment provided a robustness advantage towards lethal heat stress treatment, and also conferred cross-protection towards lethal acid stress, whereas no increased resistance towards lethal oxidative stress was observed upon mild heat stress pretreatment ( Figure 2b ). WebSep 15, 2024 · De Kegel et al. identified 22 features predictive of robust synthetic lethality between paralog pairs in cancer and used these features to develop a classifier that generates interpretable predictions of synthetic lethality for ∼36.6k human paralog pairs.
Robustness and lethality
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WebApr 13, 2024 · Lethal and nonlethal effects of parasites do not work in isolation, but rather, can act jointly on hosts and indirectly impact other species in the community such as primary producers and can alter basal resources. ... To examine how robust our results were to trematode identity, we also ran these analyses using only the most common … Web1 day ago · In New Mexico, the rate of police using lethal force is even higher if a Black resident is involved. Black people total around 2.7% of the state's population, yet they are nearly four times more ...
WebRobustness and lethality in multilayer biological molecular networks Downloadable! Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. WebHere we propose a comprehensive framework for understanding how the interactions …
To define a baseline for the robustness of the real biological molecular networks, we considered multiple versions of randomized models: (1) intra-layer randomized versions, where the randomization occurs within the gene regulatory, PPI, or metabolic layers; and (2) interlayer randomized versions, where … See more According to the central dogma of molecular biology, DNA is transcribed into RNA which is then translated into protein products. Moreover, many proteins can … See more To investigate how the couplings between the gene regulatory and PPI networks contribute to defining the system structure and function, we compared the effects … See more Gene perturbations can propagate to the metabolic network through the failure of enzymes. For example, consider the gene TCF7L2, one of the most replicated type … See more In a typical scenario, to quantify the multilayer network’s robustness, one needs to perform simulations on large-scale networks, which is time-consuming and … See more WebOct 15, 2015 · This suggests that the increase in total number of genes in humans as compared with that in yeast yielded a system of higher complexity rather than more robustness through added redundancy. Nonessential human genes appear to frequently engage in synthetic lethal interactions.
WebRobustness is a prominent feature of most biological systems. Most previous related …
WebNov 1, 2004 · Robustness is a ubiquitous feature of biological systems. It ensures that … dewey community church fisher ilWebRobustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a heterogeneous … dewey company uses the weighted-averageWebJan 1, 2014 · The Centrality-Lethality Hypothesis states that proteins with a higher degree centrality are more likely to be lethal, i.e. proteins involved in more interactions are more likely to cause death ... church of the nazarene brainerd mnWebThis report shares findings that support the concurrent and predictive validity of the DVSI-R and show that it is robust in its applicability. The findings further show that incidents involving multiple victims are highly … church of the nazarene bangor niWebDec 1, 2024 · library.stanford.edu church of the nazarene bethlehemWebJun 26, 2024 · First, by definition, these genetic interactions result in lethality, making mutant recovery and identification difficult. Second, many synthetic lethal interactions are condition-dependent... church of the nazarene bradford paWebNov 27, 2024 · Robustness is a prominent feature of most biological systems. Most previous related studies have been focused on homogeneous molecular networks. Here we propose a comprehensive framework for understanding how the interactions between genes, proteins and metabolites contribute to the determinants of robustness in a … dewey compton