Human ether-à-go-go–related gene
Web14 okt. 2012 · hERG的全称是human ether-a-go-go related gene。它是从人的海马神经中分离出来的基因。hERG基因编码形成电压激活延迟内向整流的钾离子通道（Ikr）,大量分 … Web1 okt. 2024 · Amongst various ion channels in the heart, the human ether-à-go-go-related gene (hERG) channel is an important off-target for drugs that induce cardiotoxicity. …
Human ether-à-go-go–related gene
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WebHeteromeric Assembly of Human Ether-à-go-go-related Gene (hERG) 1a/1b Channels Occurs Cotranslationally via N-terminal Interactions* - Journal of Biological Chemistry Volume 282, ISSUE 13, P9874-9882, March 2007 Heteromeric Assembly of Human Ether-à-go-go-related Gene (hERG) 1a/1b Channels Occurs Cotranslationally via N-terminal … WebCardiotoxicity is a side effect that plagues modern drug design and is very often due to the off-target blockade of the human ether-à-go-go related gene (hERG) potassium channel. To better understand the structural …
WebhERG (de l'anglais : human Ether-à-go-go-Related Gene) est un canal potassique important, c'est-à-dire une protéine jouant le rôle de canal ionique.Elle est voltage … Web3 feb. 2015 · 所谓 ether-a-go-go gene是这么来的： 最早在果蝇中发现，携带这个gene突变的果蝇对于乙醚处理昏迷时，它们的腿会不停地抖动、抽搐就像在跳舞一样，所以才是a …
Web13 jan. 2010 · Abstract. Several noncardiovascular drugs have the potential to induce Torsades de Pointes cardiac arrhythmias via blockade of the rapid component of the … hERG (the human Ether-à-go-go-Related Gene) is a gene (KCNH2) that codes for a protein known as Kv11.1, the alpha subunit of a potassium ion channel. This ion channel (sometimes simply denoted as 'hERG') is best known for its contribution to the electrical activity of the heart: the hERG channel … Meer weergeven hERG forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K ) ions out of the muscle cells of the heart (cardiac myocytes), … Meer weergeven Loss-of-function mutations in this channel may lead to long QT syndrome (LQT2), while gain-of-function mutations may lead to short QT syndrome. Both clinical disorders stem from ion channel dysfunction (so-called channelopathies) that can … Meer weergeven Due to the documented potential of QT-interval-prolonging drugs, the United States Food and Drug Administration issued recommendations for the establishment of a cardiac safety profile during pre-clinical drug development: ICH S7B. The … Meer weergeven HERG has been shown to interact with the 14-3-3 epsilon protein, encoded by YWHAE. Meer weergeven A detailed atomic structure for hERG based on X-ray crystallography is not yet available, but structures have recently been solved … Meer weergeven This channel is also sensitive to drug binding, as well as decreased extracellular potassium levels, both of which can result in … Meer weergeven The hERG gene was first named and described in a paper by Jeff Warmke and Barry Ganetzky, then both at the University of Wisconsin–Madison. The hERG gene is the human homolog of the Ether-à-go-go gene found in the Drosophila fly; Ether-à-go-go was … Meer weergeven
WebHER2 human epidermal growth factor receptor 2 ヒト上皮細胞増殖因子受容体2 hERG human ether-à-go-go-related gene ヒト遅延整流性カリウムイオンチャネル遺伝 子 …
Web12 apr. 2016 · Human ether-à-go-go related gene (hERG) 1 channels conduct the rapid delayed rectifier K + current (I Kr) and are essential for the repolarization of the cardiac action potential. hERG1... how to stop notifications on my iphoneWebBioAssay record AID 1671200 submitted by Tox21: Human Ether-a-go-go-Related Gene (hERG) channel small molecule antagonists: fluorescence cell-based qHTS assay. … how to stop notifications on nextdoorWeb8 okt. 2024 · Long QT syndrome (LQTS) is a hereditary disease that predisposes patients to life-threatening cardiac arrhythmias and sudden cardiac death. Our previous study of the … how to stop notifications on snapchatWeb25 jul. 2024 · A pharmacological inhibitor of the temperature sensitive hERG (human ether-a-go-go related gene) phenocopies the excitability effects of ziram but only at elevated … how to stop notifications on truth socialWeb15 dec. 2010 · In vitro screens using cellular preparations expressing human Ether-à-go-go related gene (hERG) potassium channels have become an intrinsic tool for evaluating … how to stop notifications on laptop screenWeb3 mei 2024 · Inhibition of human ether-à-go-go-related gene K. currents expressed in HEK293 cells by three gingerol components from ginger. Journal of Pharmacy and … how to stop notifications on discord pcWeb1 mrt. 2014 · Human ether-à-go-go-related gene gain-of-function mutations N588K and L532P favour reentry by shortening the effective refractory period in combination with a … read dr stone manga