WebMar 4, 2024 · Furthermore, dwarf open reading frame (DWORF), a sarcoplasmic reticulum-located micropeptide, activates sarcoplasmic endoreticulum calcium ATPase (SERCA), which is a target candidate for gene therapy of heart failure,, and prevents pathological remodeling and Ca 2+ dysregulation in a model of heart failure. WebThe competition between DWORF and PLN can be assumed in a way that while they preferably bind to distinct, strictly consecutive conformations that cannot coexist, they remain bound with lower affinity to other conformations but then can be outcompeted when another micropeptide has higher affinity to that conformation.
Micropeptide hetero-oligomerization adds complexity to the …
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The cardiac translational landscape reveals that ... - Molecular …
WebOct 9, 2024 · Researchers have discovered a micropeptide molecule that can restore normal heart function in mice, according to a study in eLife . The micropeptide works by preventing calcium dysregulation... WebSep 3, 2024 · PLB competes for SERCA binding with another membrane micropeptide expressed in the heart, dwarf open reading frame (DWORF) (25), shown in red in Figure … WebMay 13, 2016 · This year, some of the same authors as well as others have published a new paper in Science with similar results – they describe another lncRNA-derived micropeptide, DWORF, that activates SERCA... song thai on 5th ave